On the Hunt for a Non-Addictive Pain Reliever

Editorial Team

SpringBoard Recovery was born from the passion and personal experience of its founders. We understand the real-world challenges of early recovery and are here to help and we are passionate about helping our clients lead balanced, healthy, and fulfilling lives.


Is a Non-Addictive Pain Reliever Coming?

Opioids have been used for thousands of years, and their addictive properties have been well-known and documented since the beginning. Despite the known dangers of opioids, however, these drugs continue to be the most popular and widely prescribed painkillers, making them accessible to the public and feeding the growing opioid epidemic.

A big part of the reason for the enduring popularity of opioids is their effectiveness. There simply are no other painkillers on the market that can effectively manage serious pain symptoms. Non-steroid anti-inflammatory drugs (NSAIDs) like acetaminophen help by reducing inflammation, but they are not effective against all types of pain. They can also lead to organ damage when taken routinely, making them a poor choice for people with chronic pain.

Unfortunately, despite their efficiency at managing pain, opioids have additional unwanted effects. The first problem is the feeling of euphoria they can produce in the user, making them attractive for abuse and recreational usage. The second is the issue of chemical dependency. Even people who are not addicted to opioids can experience physical withdrawal symptoms after ceasing a dose.

For this reason, the medical community has been working on finding and developing an opioid alternative that could be used to manage pain without the same risk of addiction and abuse.

Opioid Addiction and the Search for Alternatives

Opioids work by attaching to specific receptors in the brain. The body creates its own opioids in small quantities, which is why these receptors exist in the first place. By introducing additional opioids into the system, the receptors can be prompted to send a signal through the body. The result is neurotransmissions that block pain reception and provide calmness as the body is flooded with dopamine, a neurotransmitter responsible for feeling pleasure.

Opium was the original opioid, and in a natural form it has been in use for several thousand years. A purified version, morphine, was invented in 1805, providing more reliable dosing as well as a more effective high. Since that time, a variety of opium-based painkillers have been created, some of them synthetically produced to reflect the chemical makeup of opium. Modern opiate painkillers include Vicodin® , OxyContin®  and Percocet® .

The challenge in creating a non-addictive pain reliever lies in finding alternatives to opioids that will be similarly effective.

Because of their chemical makeup and the way they work on the body, opioids will always have the potential for abuse and addiction. However, finding an alternative that is just as effective without the unwanted side effects of chemical dependency and abuse-encouraging euphoria has proven to be a challenge. OxyContin® , for example, was originally invented and advertised as being a non-addictive alternative; this turned out not to be the case, and OxyContin®  addiction continues to be a problem. Pharmaceutical manufacturers will need to be careful to avoid the same fate with future drugs.

The Future of Non-Addictive Pain Relievers

Researchers are investigating a number of potential solutions for effective but non-addictive painkillers.

One option may be to formulate drugs with specific blockers in them, allowing the opioid substances to bind with some receptors but not others. The effect would, in theory, allow the drug to suppress pain without creating the effects of euphoria or stimulating an addictive response.

Another option is to research drugs that could affect different parts of the brain. For example, researchers have discovered that a specific protein ion channel is responsible for delivering pain signals to the brain; a drug that could prevent that channel from opening could effectively block pain signals without affecting brain chemistry. Other solutions may be discovered and researched in the future.

Whatever happens, it’s important to know that the chemical make-up of a drug is only part of what makes it addictive. Addiction is complex, and understanding all of the underlying causes driving drug abuse and overdose is just as important as looking for modern painkiller alternatives. Even if all of the painkillers in the world could be immediately replaced with non-addictive alternatives, some people would still struggle with addiction.

That’s why SpringBoard Recovery works individually with patients to provide support and assistance for those seeking to kick their addictive habits and begin their recovery journey.


  1. National Institute on Drug Abuse: https://www.drugabuse.gov/drug-topics/opioids
  2. MedlinePlus: https://medlineplus.gov/opioidmisuseandaddiction.html
  3. National Institute on Drug Abuse: https://www.drugabuse.gov/sites/default/files/rx_drugs_placemat_508c_10052011.pdf
  4. MedicineNet: https://www.medicinenet.com/nonsteroidal_antiinflammatory_drugs/article.htm
  5. Centers for Disease Control and Prevention: https://www.cdc.gov/drugoverdose/opioids/index.html
  6. National Institute on Drug Abuse: https://www.drugabuse.gov/news-events/nida-notes/2019/02/promising-alternative-to-opioid-pain-medications
  7. NAABT: https://www.naabt.org/faq_answers.cfm?ID=6#
  8. Partnership to End Addiction: https://drugfree.org/drugs/opium/#:~:text=Opium%20is%20an%20opioid%20or,or%20taken%20in%20pill%20form.
  9. Medical News Today: https://www.medicalnewstoday.com/articles/323465
  10. Healthline: https://www.healthline.com/health/addiction

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NOVEMBER 13, 2017

Robert Castan is a member of the Executive Leadership Team at SpringBoard Recovery. Robert started his professional career as a house manager and has become an industry leader and trusted voice in the treatment world. He brings extensive knowledge of organizational growth, industry-leading outcomes, and comprehensive marketing to SpringBoard Recovery. Robert has been walking his own path of recovery for over 10 years. This path has truly driven his ambition to help make treatment available to others who are struggling with addiction. Robert finds great joy in traveling and keeping physically active, with an emphasis on biking. Robert resides in Arizona with his husband and two four-legged children.   The U.S. Alcohol Crisis, Still Deadlier Than the Opioid Epidemic   Zombies and Other Future Threats to the Health of American Youth Dire Mental Health: A Catalyst for Post-Pandemic Drug Addiction The Benefits of Rehab Center Staff Working Their Own Recovery Opinion: The Opioid Crisis + COVID-19 = The Perfect Storm Robert Castan on Successful Addiction Treatment and Entrepreneurship Castan: The road less traveled of addiction & recovery in Scottsdale Opioids & COVID Driving Phoenix’s Rising Fatal Drug Overdoses Opinion: The Opioid Crisis + COVID-19 = The Perfect Storm Successful Addiction Treatment Programs & Entrepreneurship

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